Disinfectant and antiseptic embodying furane derivatives and process for making and utilizing same



Patented Dec. 10, 1929 within the desired limits.

UNITED-STATES PATENT OFFICE JOHN P. TRIOKEY, OF EVANSTON, AND CAR-L S. MINER, OF CHICAGO, ILLINOIS, .AS-

SIGNORS TO THE QUAKER OAT COMPANY, OF CHICAGO, ILLINOIS, A CORPORATION OF NEW J EB-SEY DISINFECTANT AND ANTISEPTIO EMBODYING FURANE DERIVATIVES AND'PROCESS L FOR, we AND u'rrnrzme sum No Drawing.

Our invention relates to improved disinfecants and antiseptics which may embody furane derivatives and also to improved methods and processes for treating and utilizing furane derivatives.

Certain furane derivatives such as furfural fungicidal properties. Thevapor of furfural is very effective as a disinfectant and antiseptic if properly utilized and accordingly one purpose of our present invention is to provide means for liberating such vapors in close proximity to the organic or other material which is to be preserved by the treatment thus insuring substantially the maximum efficiency in their use. A further object of our invention'is to provide a process and means forefiiciently liberatin vapors of furane derivatives having disin ecting and antiseptic properties at a gradual and controlled rate and-over a substantial period oftime.

A further aim of our invention is the provision of certain furane derivatives such as furfuramide and furfurine in a dry pow dered form which is not subject to undesirable changes during storage and use. Un d'er ordinary conditions 'of storage powdered furfuramide and furfurine sometimes become caked or transformed into solid masses, but by our invention this condition is avoided and materials in a relatively stable and desirable form for use as disinfectants and germicides are provided.

Another object of our invention is to provide means for using such powdered or finely divided material as an intiseptic orrgermicide in a form such that the active material will be present only in the desired concentration. and such that when vapors are liberated therefrom their toxic effect may be controlled Furthermore, the obj ects of our inven tion include the rovision of a germicide and antiseptic which possesses no disagreeable odor, is freefrom deleterious effects upon the skin and mucous membranes of the user, and the eflects of which may be controlled so that it is substantially non-toxic to the material treated. We also have in this invention proyided a preservative which is economical of possess strongly germicidal, bactericidaland with the seed. The natural moisture of the Application filed August 23, 1924. semi No. 733,763.

production and convenient in use and which may be kept in storage without the occurrence of undesirable changes therein.

' Wehave found that furane derivatives such as furfuramide may be used as effective germicides or fungicides upon various organic materials, especlally if such materials are accompanied by moisture. The moisture causes a decomposition of the furane derivative and the liberation of vapors having the desired germicidal or antiseptic effect. For example, furfuramide in moist air will decompose and liberate vapors comprising furfural and ammonia. However, under most conditions,

fu'rfuramide, furfurine and other furane derivatives in. the presence of small amounts of moisture will decompose too rapidly thus producin vapors in quantities which may be strong ytoxic to the plant or otherhost which is being treated. Furthermore, it is often diflicult to uniformly distribute the pure powdered .furfurine and furfuramide except in such quantities that the resulting furfurfal vapors will be of an excessive con centration injurious to the organic matter treated.

We have found that if furfurmideor furfurineare associated with quantities of inert material, such 'as' infusorial earth or the like, they may be satisfactbrily diluted and the ated, but in quantities insuflicient to render the vap'ors toxic to the plants or other organ c matter treated.

As a fungicide on plants, we have found 5 atmosphere without the occurrence of exothermic reactions or undersirable changes therein. -Whenused, the powder may be blown or sprinkled over the plants or mixed plants and surrounding atmosphere will be suflicient to slowly cause decomposition of the furfuramide, thus furfural and ammonia germicidal vapors may be gradually liberproportion of inert material which has been used. Since the vapors are liberated in very close proximity ,to the points where they are actually eifective, this method is obviously very eflicient and necessitates the use of only a: small quantity of the material. Furthermore, the vapors being produced only gradually, the effect is prolonged over a substantial .period of time and yet at no time are f the mixture to a temperature of 100120 0;,

.whereby the furfuramide is converted to fur furine.

It will be apparent from the foregoing that the effective concentration of furfuramide, furfurine and other similar material's may be controlled in a like manner, regardless of the particular use for which these chemicals are intended, whether as germicides or as reagents in other 'p'rocessesfor arts.

It is not intended that this invention be limited by the above specific description, but itis to be understood that we are to be limited only by the following claims or as may be required by the prior art. 7

Having thus described our invention, what we claim as new and desire to secure by Letters Patentof the United States, is:

- 1. The process of preserving organic material in the presence of natural moisture which comprises treating the material with a finely divided substance comprising furfuramide and inert earth whereby furfural vapor is gradually liberated a'sa result of the reaction of furfuramide with the moisture, excessive concentration of the furfur-\ amide being avoided by the use of the inert earth.

2. The methodof utilizing germicidal and fungicidal properties of ainmonia de- 'rivatives or furfural which comprises chemically liberating furfural vapors at a retarded rate and in close proximity to the material to be preserved.

3. The method of utilizing the germicidal and fungicidal properties of furane derivatives which comprises liberating vapors'in a predetermined concentration in proximity to the material to be preserved by the reaction of moisture with furfuramide associated with inert earth.

4. The process of preserving organic material which comprises treating the material with an antiseptic comprising furfuramide associated withpredetermined quantities of infusorial earth.

terial which comprises treating-the material with a disinfectant comprising an ammonia derivative of furfural that liberates furfural vapors associated with predetermined quantities of infusorial earth whereby U furfural vapors are liberated in close proximity to the organic material to be preserved.

5. The process of preserving organic mai 6. The process of preserving organic matewith a disinfectant comprising a finely divided solid ammonia derivative of furfural that liberates furfural vapor associated with predetermined quantities of infusorial earth.

gradually decomposes inthe presence of mois ture and liberates furfural vapor in a controlled concentration.

rial which comprises treating the material 10. A germicide and fungicide comprising inert earth associated with an ammonia derivative of furfural which liberates furfural vapor graduallyfunder the conditions of use of the antiseptic.-

11. A germicide furfuramide. A

12. A germicide and fungicide comprising furfuramide associated with an inert-carrier.

and fungicide comprising 13. A germicide and fungicide comprising furfuramide associated with an inert earth in relative proportions such that the rate of decomposition of the furfuramide is re-' tardedunder the natural conditions of use of said preservative and antise tic.

14. A germicide and fungici e com rising a' fplrfuramide associated with in sorial eart 15. A germicide and fungicide comprising scribed our names.

' JOHN P. TRICKE Y.

- g CARL MINER. 

